Endocrine Abstracts

Thyroid cancer is the commonest malignancy seen in endocrine practice. Audits of clinical practice have revealed significant variations in management, and the British Thyroid Association have published guidelines (2002) to address this. The aim of our study was to assess the care-stage at which practice falls short of agreed standards. We performed retrospective case note review of 83 patients (72 female) followed in a specialist thyroid cancer clinic over 5 years. Histology d...

Background: Leptin is a multi-functional hormone of which low levels are associated with immuno-deficiency. We and others have shown that leptin promotes secretion of inflammatory cytokines (TNF-alpha and IL-6) by monocytes (1) and activated lymphocytes (2). The leptin receptor (Ob-R) is expressed on neutrophils and leptin enhances oxidative species production by stimulated neutrophils.Aim: To access whether CD11b expression on human neutrophils is a di...